《设计临床研究》经过广泛的修订，继续作为医生、护士、药剂师和其他参与各种形式的临床、转化和公共卫生研究的卫生专业人员的实用指南。它以方便读者的方式介绍了先进的流行病学概念，并就设计、资助和实施中涉及的挑战性判断提出了常识性的方法。

本版新增内容。

每一章的内容都得到了扩充和更新，新材料包括： - 用于比较有效性研究的非劣效性试验--发病率-密度病例对照研究--混杂和效应修饰--为预测规则提供信息的诊断测试研究--全基因组测序的伦理问题--自动数据管理方法--新的NIH拨款写作要求。

彩色格式和电子访问，由Inkling™提供支持，作为文本的免费补充 - 可通过浏览器查看或下载到平板电脑或智能手机 - 完整的文本与优化的导航 - 笔记共享、高亮和书签功能 - 参考资料和内容的交叉链接 - 链接到新词汇表的快速搜索选项。

Designing Clinical Research has been extensively revised and continues to set the standard as a practical guide for doctors, nurses, pharmacists, and other health professionals involved in all forms of clinical, translational, and public health research. It presents advanced epidemiologic concepts in a reader-friendly way, and suggests common sense approaches to the challenging judgments involved in designing, funding, and implementing.

New to this edition:

Expanded and updated content in every chapter, with new material on: • non-inferiority trials for comparative effectiveness research • incidence-density case-control studies • confounding and effect modification • diagnostic test studies to inform prediction rules • ethical aspects of whole genome sequencing • automated data management approaches • new NIH grant-writing requirements

Color format, and Electronic access, powered by Inkling™ as a free companion to the text • viewable through your browser or as a download to tablet or smartphone • the complete text with optimized navigation • note-sharing, highlighting and bookmarking capability • cross-linking of references and content • rapid search options linked to the new glossary